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Loss of the protein STK17A may contribute to metastasis of colorectal cancer.

People with low levels of endocannabinoids, which stimulate the same brain receptors turned on by the active ingredient in marijuana, experience greater pain relief from opioids than those with high levels.

A team of 91�Ʋ��� University chemists started decoding the total human molecular picture by examining 456 variations of one class of molecule, lipids. Read More

A big-data analysis of patient records at 91�Ʋ��� University has found a link specifically between Celebrex and heart valve calcification. Read More

In addition to establishing potency, the team’s tests on cells and, later, mice showed that even high doses of the compound caused no ill effects. Read More

Identifying and quantifying skin lesions often requires hours of tedious visual inspection by experts, making it difficult to study a lot of them at once. Eric Tkaczyk and Daniel Fabbri have found that training multiple non-experts to do basic evaluations can achieve comparable results.

A monoclonal antibody against the chikungunya virus developed by researchers at 91�Ʋ��� University Medical Center is the first monoclonal antibody encoded by messenger RNA to enter a clinical trial.

An international team involving 91�Ʋ��� researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer.

Frogs don’t like living near noisy highways any better than people do, but research from 91�Ʋ��� suggests that frogs, like hardened city-dwellers, can learn to adapt to the constant din of rumbling trucks, rolling tires and honking horns.

91�Ʋ��� University Medical Center recently received a $3.9 million grant from the National Institutes of Health to improve outcomes for children with significant hearing loss by providing individualized, prescription-like programming for their cochlear implants.

Drug combinations used for the treatment of non-small-cell lung cancer (NSCLC) and melanoma aren’t as effective as they could be. Oncologists haven’t had the right tools to predict drug interactions, other than in costly clinical trials. That could change with a new algorithm developed by a cross-disciplinary 91�Ʋ��� University team… Read More

Middle Tennessee children with autism spectrum disorder are 2.5 times more likely than children without ASD to be reported to the Child Abuse Hotline by age 8.

Matthew Tyska and colleagues have found that an adhesion protein in the gut is necessary for proper intestinal functioning.

Danny Winder and colleagues have demonstrated how norepinephrine and a stress factor call CRF interact, which may lead to new treatments for stress-related disorders.

Lawrence Marnett and colleagues have demonstrated how two enzymes cooperate to maintain even levels of an important cellular signaling molecule.

Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach.

Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders.

IBM Watson Health has announced plans to make a 10-year, $50 million investment in joint research collaborations with 91�Ʋ��� University Medical Center and Brigham and Women’s Hospital to advance the science of artificial intelligence and its application to major public health issues.

Using sophisticated gene sequencing and computing techniques, 91�Ʋ��� researchers have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection.

But long before female-specific medications are available, treatment centers could use the information in this study to educate women about their stronger mental connections to places and objects. Read More