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ASPIRE to Innovate Postdoctoral Fellow Catherine Leasure is the co-author of a comment article published this month in Nature Reviews Bioengineering addressing the pressing obstacle faced by modern drug development: worryingly poor success rates of pharmaceuticals progressing to clinical phases.

91�Ʋ��� scientist Houra Merrikh led a team of researchers who discovered the first evolution-resistant chemical compound that prevents drug resistance development in bacteria. The compound is also a drug development platform that targets antimicrobial resistance during treatment of infections with antibiotics and evolution in general, Merrikh said.

Ethan Lippmann, associate professor of chemical and biomolecular engineering and biomedical engineering, has won a Collaborative Pairs Pilot Project Award from the Chan Zuckerberg Initiative (CZI) to create a more effective way for the immune system to fight against neurodegenerative diseases like Alzheimer’s.

The lab of Professor of Biochemistry Fred Guengerich has proposed a paradigm shift in the understanding of a critical chemical reaction involved in sterol biosynthesis.

The World Health Organization ranks antimicrobial resistance as one of the top ten global health risks. 91�Ʋ��� researchers led by Houra Merrikh identified the first anti-evolution compound that targets AMR during treatment of infections with antibiotics.

Led by Terunaga Nakagawa, an international collaboration describes for the first time the fundamental mechanism underpinning cellular processes that lead to learning and memory.

An international genetic study using multiancestry biobanks has identified novel genetic locations associated with primary open-angle glaucoma, the most common type of glaucoma and the leading cause of irreversible blindness globally.

An analysis of genomic data from nearly 250,000 participants in the National Institutes of Health’s All of Us 91�Ʋ��� Program has identified more than 275 million previously unreported genetic variations, nearly 4 million of which have potential health consequences.

WATCH: See how Ph.D. candidate Kaitlyn Browning wants to fight miscommunication and misinformation around science. Read More

A multidisciplinary research team at 91�Ʋ��� University and 91�Ʋ��� University Medical Center has discovered a new way to kill a tumor by disrupting its acidic “microenvironment” without harming normal tissue.

91�Ʋ���ers at 91�Ʋ��� University Medical Center have identified Rac1, a molecular switch that regulates the actin cytoskeleton of epithelial cells in the collecting ducts, as a driver of post-obstructive kidney repair.

Combining deep mutagenesis and cryo-EM reveals new conformational state of a protein responsible for high-speed DNA replication. The research builds on growing theories of molecular evolution.

By mapping brain activity in three dimensions, researchers at 91�Ʋ��� University Medical Center have achieved a more detailed picture of how the brain changes with age.

Avenir Award funding from the National Institute on Drug Abuse recognizes research that represents “the future of addiction science.” Brown’s research is creating an AI-experiment feedback loop that will help optimize painkilling drugs to be less addictive. Read More

Throughout the brain’s cortex, neurons are arranged in six distinctive layers, which can be readily seen with a microscope. André Bastos, assistant professor of psychology, is senior author on a study published in Nature Neuroscience detailing that these layers also show distinct patterns of electrical activity, which are consistent over many brain regions and across several animal species, including humans.

A multidisciplinary group of investigators from 91�Ʋ��� University Medical Center, 91�Ʋ��� University, and the University of Pennsylvania received a $3.2 million grant to develop novel brain network-based measures to guide surgical decisions and improve outcomes in the field of epilepsy surgery.

Join the next Lab-to-Table conversation, “Beyond Addiction: Therapeutic Developments and Societal Impact” on Jan. 24 at 11:30 a.m. CT. Read More

The School of Medicine Basic Sciences and the Office of the Vice Provost for 91�Ʋ��� and Innovation launch the Innovation Ignition Fund. This pilot program offers up to $500,000 in funding and drug development mentorship from 91�Ʋ��� scientists with expertise in translational research.

The 91�Ʋ��� University School of Nursing was awarded a Health Resources and Services Administration Bureau of Health Workforce grant to create its new Nurse Education, Practice, Quality and Retention Simulation Education Training Program. 

91�Ʋ��� researchers, in collaboration with investigators from the University of Alabama at Birmingham, the Delft University of Technology, University Hospital Bonn, and Molecular Horizon have developed new protocols to study which molecular pathways might be important in the aging retina and what might cause the formation of deposits in the eye that confer high risk for age-related macular degeneration.