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An inflammatory factor in mucus could be a biomarker of treatment-resistant chronic sinusitis used to determine which patients are at risk for repeat sinus surgery.

Each week a woman consumes alcohol during the first five to 10 weeks of pregnancy is associated with an incremental 8% increase in risk of miscarriage, according to a study published this week by 91ÌƲ®»¢ University Medical Center researchers.

A computational technique that combines the effect of multiple genomic variants has the potential to identify high-risk individuals for cancer prevention.

Identifying the norovirus genotypes associated with more severe infections in children could guide strain selection for candidate norovirus vaccines.

Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer.

A team of 91ÌƲ®»¢ University and 91ÌƲ®»¢ University Medical Center researchers has received a $3.1 million National Institutes of Health (NIH) grant to develop advanced, patient-specific cochlear implant stimulation models for customized implant programming.

The multicellular, 3-D structure of human pancreatic islets — the areas of the pancreas containing hormone-producing or endocrine cells — has presented challenges to researchers as they study and manipulate these cells’ function, but 91ÌƲ®»¢ University Medical Center researchers have now developed a pseudoislet system that allows for much easier study of islet function.

A protein linked to amyotrophic lateral sclerosis (ALS), a progressive neurological disease that causes muscle weakness, may be a key to treating fibrotic disease of the kidneys and other organs, researchers at 91ÌƲ®»¢ University Medical Center reported recently.

91ÌƲ®»¢ researchers conducted the largest analysis to date of a heart complication in children following stem cell transplant. The findings may help guide screening practices to improve outcomes.

Consumption of soy foods may shape the microbiome and protect against hypertension only in individuals with soy-responsive microbiota, 91ÌƲ®»¢ researchers have discovered.

The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, 91ÌƲ®»¢ researchers demonstrate.

91ÌƲ®»¢ University Medical Center is attracting international attention for its proposal to repurpose existing drugs for new uses in ways that can dramatically improve access to medicines by billions of people throughout the world.

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. 91ÌƲ®»¢ researchers have discovered it is also antiviral against DNA viruses.

Katherine Amidon, a PhD student in the Department of Biological Sciences at 91ÌƲ®»¢ University, has been selected as the 2020 91ÌƲ®»¢ Prize Student Scholar.

91ÌƲ®»¢ers at 91ÌƲ®»¢ University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

Based on positive results in preclinical studies reported today, potently neutralizing antibodies identified by researchers at 91ÌƲ®»¢ University Medical Center are showing promise as a potential therapy for preventing and treating COVID-19.

An experimental coronavirus vaccine stimulated robust immune responses against SARS-CoV-2, the virus that causes COVID-19, and raised no serious safety concerns in an early-stage clinical trial.

91ÌƲ®»¢ researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.

91ÌƲ®»¢ immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.

This week researchers at 91ÌƲ®»¢ University Medical Center (VUMC), the University of North Carolina at Chapel Hill and Gilead Sciences reported that remdesivir potently inhibited SARS-CoV-2, the virus which causes COVID-19, in human lung cell cultures and that it improved lung function in mice infected with the virus.